BCG Vaccine may be working against Corona

The humble century-old BCG vaccine taken by every child in India could be the answer to fight Coronavirus, researchers in various countries are looking at this angle especially when a mutation in India is comparatively low than Europe where this vaccination is not so common nowadays.

Researchers in several countries are testing the century-old tuberculosis vaccine to see if it can give a boost to the immune system to help it fight off the novel coronavirus now causing the COVID-19 pandemic.

The #BCGcorona study investigates if healthcare workers are better protected against coronavirus after vaccination against tuberculosis (BCG vaccine). It provides a boost to the immune system, which may lead to improved protection and/or milder infection https://t.co/h3wZdg5EF0 https://t.co/XUxV4cOTZR pic.twitter.com/yPh86MTHGk

— Infection & Immunity UMC Utrecht (@IenI_UMCUtrecht) March 27, 2020

Clinical trials of the BacilleCalmette-Guerin (BCG) vaccine, which was first developed in the early 1920s,are planned in Europe and Australia to see if it can help reduce the prevalenceand severity of COVID-19 symptoms.

Researchers from the Murdoch Children's Research Institute (MCRI) in Melbourne are currently working to enrol 4,000 healthcare workers from hospitals around Australia in one study.

"This trial will allow thevaccine's effectiveness against COVID-19 symptoms to be properly tested, andmay help save the lives of our heroic frontline healthcare workers," MCRIDirector Professor Kathryn North said in a release.

Surprising data from Germany shows ex-East German states where BCG vaccination at birth was mandatory see fewer per capital cases of C19.
Can discount "third-world" data but hard to explain German data considering open borders and better testing. pic.twitter.com/W9BMl7NjFa

— S◎L◎N (gm, gm) (@chimpvc) March 30, 2020

A separate large-scale study isplanned to include older patients and health care workers at several hospitalsin Germany and similar trials are in the works in the Netherlands, the UK andGreece.

This work is very different from the efforts underway to develop a vaccine to confer specific immunity to the novel coronavirus, SARS-CoV2. BCG has a spotty track record giving immunity against even the disease it was developed for, tuberculosis. But as one of the few tools available to fight that disease, it has stuck around for decades and a number of studies have shown that it seems to offer other benefits.

Correlation between universal BCG (TB vaccine) vaccination policy and reduced morbidity and mortality for COVID-19: an epidemiological study https://t.co/2nk8oc19bJ pic.twitter.com/E85Drjxzgz

— TB_NewsDaily (@TB_NewsDaily) March 28, 2020

Scientists at the Max PlanckInstitute for Infection Biology developed the vaccine candidate VPM1002 basedoff of BCG earlier this century, which will be used for the trial starting soonin Germany. VPM1002 has been shown to protect the respiratory tracts of micefrom viral infections.

 "In addition, VPM1002 can be manufacturedusing state-of-the-art manufacturing methods which would make millions of dosesavailable in a very short time", says Adar C. Poonawalla, CEO and ExecutiveDirector, Serum Institute of India in a statement.