The two drug dealers have been identified as Mantu Kumar Deb (45) and Subash Das (33).
Both are residents of Assam's Karimganj district. The two peddlers were arrested on Thursday evening near Sairang village, around 20 km from Aizawl, they said.
Their truck was intercepted during a random checking of vehicles and 50 kg of meth tablets were found inside it, police said.
As per reports, a case was filed under relevant sections of the Narcotic Drugs and Psychotropic Substances Act, 1985, they said.
Further investigations are underway, police said.